Article 2023 · 1 citations

Effect of Taxifolin on Lung Injury Induced by <i>Staphylococcus aureus</i> in Albino Wistar-Type Rats: A Biochemical and Histopathological Evaluation

Dabanlioglu, Bulent, Suleyman, Bahadir, Mammadov, Renad, Yavuzer, Bulent, Altuner, Durdu, Akkas, Onder, Mokhtare, Behzad, Coban, Taha Abdulkadir, Suleyman, Halis

Abstract

Background and Objective: Staphylococcus aureus is considered the main cause of pneumonia. Pneumonia is the most common cause of acute lung injury. Taxifolin is a flavonol with antioxidant, anti-inflammatory, antimicrobial, antiviral, antifungal, anti-hyperglycemic, anti-hyperlipidemic, anti-psoriatic and pulmono-protective activities. The present study aimed to biochemically and histopathologically investigate the protective effect of taxifolin against possible acute lung oxidative and inflammatory damage caused by Staphylococcus aureus ( S. aureus) infection in rats. Materials and Methods: The rats were divided into three groups 6 rats each, healthy control (HG), S. aureus inoculated (SaG) and S. aureus inoculated+taxifolin treated (SaT). Animals were euthanized. Malondialdehyde (MDA) total glutathione (tGSH), Nuclear Factor kappa B (NF-kappa B), Tumor Necrosis Factor-alpha (TNF-alpha) and Interleukin One Beta (IL-1 beta) levels were measured in the excised lung tissues and also examined histopathologically. Results: S. aureus inoculation significantly increased MDA, NF-kappa B, TNF-alpha and IL-1 beta levels and decreased tGSH levels in lung tissue. Treatment with taxifolin significantly suppressed the increase in MDA, NF-kappa B, TNF-alpha and IL-1 beta levels and the decrease in tGSH levels. Histopathologically, S. aureus inoculation led to severe mononuclear cell infiltration in interstitial areas, lymphoid hyperplasia in bronchial-associated lymphoid tissue and desquamation in bronchial epithelium. Treatment with taxifolin attenuated these histopathological findings. Conclusion: Current experimental results suggested that taxifolin may be beneficial in the treatment of oxidative and inflammatory lung injury associated with S. aureus infection.

Keywords

Lung injury oxidative and inflammatory injury rats Staphylococcus aureus taxifolin NF-KAPPA-B ISCHEMIA-REPERFUSION INJURY OXIDATIVE STRESS IN-VITRO INFLAMMATION OSTEOCLASTOGENESIS PATHOGENESIS PNEUMONIA MECHANISM

WoS Categories

Pharmacology & Pharmacy

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: INTERNATIONAL JOURNAL OF PHARMACOLOGY
Year: 2023
Volume: 19
Issue: 5
Pages: 623-631
ISSN: 1811-7775
eISSN: 1812-5700
DOI: 10.3923/ijp.2023.623.631
WoS UID: WOS:001091417800003

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