Article 2023 · 9 citations

Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes

Dalkilic, Oguzhan, Turbedaroglu, Ozge, Lafzi, Ferruh, Kilic, Haydar

Abstract

Alkylated imidazopyridines are crucial structures formedicinalchemistry. Here, an efficient method for the C3-H alkylationof imidazopyridines was devised. Under Lewis acid-catalyzed conditions,reactions of imidazopyridines with different donor-acceptorcyclopropanes were carried out. Finally, 1,3-bisfunctionalizaton ofdonor-acceptor cyclopropanes was performed. In addition, synthesizedC3-alkylated imidazopyridines are amenable for diverse synthetic applications.

Keywords

ACID IMIDAZOHETEROCYCLES DERIVATIVES REACTIVITY PROTOCOL ION

WoS Categories

Chemistry, Organic

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF ORGANIC CHEMISTRY
Year: 2023
Volume: 88
Issue: 16
Pages: 11834-11846
ISSN: 0022-3263
eISSN: 1520-6904
DOI: 10.1021/acs.joc.3c01122
WoS UID: WOS:001042105800001

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