Article 2023 · 0 citations

A metabolomics study: Could plasma metabolites be a guide for the prevention of tamsulosin side effects?

Akman, T. C., Kadioglu, Y., Senol, O., Erkayman, B.

Abstract

Background. - The understanding of precision medicine, which aims for high efficacy and low toxicity in treatments, has gained more importance with omics technologies. In this study, it was aimed to reach new suggestions for low-toxicity treatment by clarifying the relationship between tamsulosin side effects and metabolome profiles. Materials and methods. - Plasma samples of control and tamsulosin-treated rats were ana-lyzed by LC-Q-TOF/MS/MS. MS/MS data was processed in XCMS software for the identification of metabolite and metabolic pathway analysis. Data were classified with MATLAB 2019b for multivariate data analysis. 34m/z values were found to be significantly different between the drug and control groups (P < 0.01 and fold analysis >= 1.5) and identified by comparing METLIN and HMDB databases. Results. - According to multivariate data analysis, ce-Linolenic Acid, Thiamine, Retinoic acid, 1.25-Dihydroxyvitamin D3-26.23-Lactone, L-Glutamine, L-Serine, Retinaldehyde, Sphingosine 1-phosphate, L-Lysine, 23S.25-Dihydroxyvitamin D3, Sphinganine, L-Cysteine, Uridine 5'-diphosphate, Calcidiol, L-Tryptophan, L-Alanine levels changed significantly compared to the control group. Differences in the metabolisms of Retinol, Sphingolipid, Alanine-Aspartate-Glutamate, Glutathione, Fatty Acid, Tryptophan, and biosynthesis of Aminoacyl-tRNA, and Unsaturated Fatty Acid have been successfully demonstrated by metabolic pathway analysis. According to our study, vitamin A and D supplements can be recommended to prevent side effects such as asthenia, rhinitis, nasal congestion, dizziness and IFIS in the treatment of tam-sulosin. Alteration of aminoacyl-tRNA biosynthesis and sphingolipid metabolism pathways during tamsulosin treatment is effective in the occurrence of nasal congestion. Conclusions. - Our study provides important information for tamsulosin therapy with high effi-cacy and low side effects in precision medicine. (c) 2022 Academie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

Keywords

Tamsulosin Metabolomics Precision medicine LC-Q-TOF/MS/ Side effects FLOPPY-IRIS-SYNDROME URINARY-TRACT SYMPTOMS BLADDER OUTLET OBSTRUCTION LIQUID-CHROMATOGRAPHY VITAMIN-D MANAGEMENT PHARMACOLOGY TOXICITY UPDATE MEN

WoS Categories

Pharmacology & Pharmacy

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ANNALES PHARMACEUTIQUES FRANCAISES
Year: 2023
Volume: 81
Issue: 2
Pages: 220-232
ISSN: 0003-4509
DOI: 10.1016/j.pharma.2022.09.004
WoS UID: WOS:000990502100001

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