Article
2023
·
6 citations
C6-H Bond Functionalization of Indoles: A New Gate
Abstract
Indoles are valuable precursors in medicinal, bioorganic, and material chemistry and particularly serve as a platform for diversity. However, the scope of the C6-functionalization of indoles was limited until recently. In this short review, we summarize developments in the C6-functionalization reactions of indoles involving transition-metal-cat-alyzed functionalization and Brunsted and Lewis acid catalyzed process -es. The regioselectivity is controlled by remote-C-H activation and hy-drogen bond formation. 1 Introduction 2 Transition-Metal-Catalyzed Functionalization 3 Acid-Catalyzed Processes 4 Conclusion
Keywords
indole
C-H bond activation
directing group (DG)
transition metal (TM)
acid catalyst
hydrogen bond
electrophilic aromatic substitution (EAS)
C-H FUNCTIONALIZATION
O-QUINONE METHIDES
ARYLATION
ALKYLATION
3-INDOLYLMETHANOLS
ACTIVATION
WoS Categories
Chemistry, Organic
Citation
- Journal
- SYNTHESIS-STUTTGART
- Year
- 2023
- Volume
- 55
- Issue
- 21
- Pages
- 3417-3433
- ISSN
- 0039-7881
- eISSN
- 1437-210X
- DOI
- 10.1055/a-2050-4897
- WoS UID
- WOS:000970376500006