Review 2022 · 29 citations

An Overview of Ischemia-Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

Guler, Mustafa Can, Tanyeli, Ayhan, Akdemir, Fazile Nur Ekinci, Eraslan, Ersen, Sebin, Saime Ozbek, Erdogan, Derya Guzel, Nacar, Tuncer

Abstract

Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion. There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1 ss, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa ss, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.

Keywords

Inflammatory response ischemia-reperfusion injury oxidative stress reactive oxygen species REACTIVE OXYGEN NECROSIS MYELOPEROXIDASE MECHANISMS INTERLEUKIN-1-BETA PATHOPHYSIOLOGY METABOLISM AUTOPHAGY PATHWAY BIOLOGY

WoS Categories

Medicine, General & Internal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: EURASIAN JOURNAL OF MEDICINE
Year: 2022
Volume: 54
Pages: S62-S65
eISSN: 1308-8742
DOI: 10.5152/eurasianjmed.2022.22293
WoS UID: WOS:000926902700010

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