Effects of simultaneous versus post exposure epigallocatechin-3-gallate treatment on aluminum induced neurotoxicity in rat hippocampus: A multi-approach study
Palabiyik-Yucelik, Saziye Sezin, Zeybek, Naciye Dilara, Cinar, Irfan, Akpinar, Erol, Zirh, Elham Bahador, Sipahi, Hande, Halici, Zekai
Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-Daspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a wellknown antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were downregulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al.
- Journal
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Year
- 2023
- Volume
- 98
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- DOI
- 10.1016/j.etap.2023.104061
- WoS UID
- WOS:000920582800001