Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case-control study
Aydin, Tugba, Dilsiz, Alparslan, Eminoglu, Didem Ozkal, Sahin, Ahmet Bedreddin, Laloglu, Esra, Bayrakdar, Yunus Emre
Objective The aim of this study was to investigate the relationship between total, free and bioavailable 25-hydroxyvitamin D levels, and periodontitis.Materials and methods Thirty-nine patients with periodontitis diagnosis and 44 healthy participants were included in this study. 25-Hydroxyvitamin D, vitamin D-binding protein, procalcitonin, and albumin levels were measured from the serum samples obtained. Free and bioavailable 25-hydroxyvitamin D levels were calculated. Total, free, and bioavailable 25-hydroxyvitamin D levels were compared between the healthy control and periodontitis groups. The association of total 25 (OH)D levels with periodontitis was tested through univariate analysis and multivariate logistic regression.Results Total 25-hydroxyvitamin D, bioavailable 25-hydroxyvitamin D, and free 25-hydroxyvitamin D levels were significantly lower in the periodontitis group than in the healthy control group (p < 0.001). In the logistic regression analysis, a significant correlation was observed between total 25-hydroxyvitamin D and periodontitis (p < 0.001).Conclusion Our study shows that there is a relationship between total, free and bioavailable 25-hydroxyvitamin D levels and periodontitis. In addition, it has been shown that the determination of free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in terms of the relationship between periodontitis and vitamin D.
- Journal
- CLINICAL ORAL INVESTIGATIONS
- Year
- 2023
- Volume
- 27
- Issue
- 1
- Pages
- 421-430
- ISSN
- 1432-6981
- eISSN
- 1436-3771
- DOI
- 10.1007/s00784-022-04844-9
- WoS UID
- WOS:000907813500002