Article 2022 · 4 citations

The Effects of Necrostatin-1 on Cerebral Vasospasm- Induced Subarachnoid Hemorrhage

Sahin, Mehmet Hakan, Akyuz, Mehmet Emin, Kadioglu, Hakan Hadi

Abstract

AIM: To investigate the effects of necrostatin-1 (NEC-1) on subarachnoid hemorrhage (SAH)-induced vasospasm in a rat model.MATERIAL and METHODS: A total of 59 male Wistar albino rats were randomly divided into six groups: control (group 1), sham (group 2), decapitation one hour after SAH (group 3), decapitation 48 hours after SAH (group 4), NEC-1 given 15 minutes before SAH and decapitation one hour after SAH (group 5), and NEC-1 given 24 hours after SAH and decapitation 48 hours after SAH (group 6). NEC-1 (1 uq) was administered intracisternally in dimethyl sulfoxide (DMSO) (2.6 uq). After decapitation, the cross-sectional areas and wall thicknesses of basilar arteries were determined histopathologically using stereological methods.RESULTS: NEC-1 administered before SAH had a statistically significant preventive effect on vasospasm following SAH. Arterial wall thicknesses were found to be significantly increased in the SAH without NEC-1 groups but not in the control group, the sham group or the NEC-1 groups.CONCLUSION: The results of this study show that NEC-1 can prevent vasospasm in rats and has cytoprotective effects. Further studies are needed for the clinical use of this agent.

Keywords

Necrostatin-1 Stereology Subarachnoid hemorrhage Vasospasm Rat EARLY BRAIN-INJURY INFLAMMATION NECROPTOSIS APOPTOSIS CYTOKINES NECROSIS CELLS

WoS Categories

Clinical Neurology Surgery

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: TURKISH NEUROSURGERY
Year: 2022
Volume: 32
Issue: 6
Pages: 923-929
ISSN: 1019-5149
DOI: 10.5137/1019-5149.JTN.35167-21.4
WoS UID: WOS:000890908200006

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