Article 2022 · 9 citations

Preparation, Characterization of Chitosan-Coated/Uncoated Boron Nanoparticles and In-Vitro Evaluation of Their Antimicrobial Effects

Ozakar, Rukiye Sevinc, Bingol, Mehmet Semih, Adiguzel, Mehmet Cemal, Ozakar, Emrah

Abstract

Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of mul-tidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates sci-entists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible properties, including cost-effectiveness. The aim of this study was to evaluate the antibacterial effect of boron nitride (BN) and chi-tosan coated BN-Nps using different surfactants. In this regard, the potential antibacterial activity of prepared chitosan-coated and non-coated BN-Nps have been investigated against nine reference bacteria strains. BN-Nps and chitosan-coated BN-Nps were successfully developed and characterized. Nps determined that showed high zeta potential values (between-20.1 mV and +59.2 mV). Antimicrobial resistance results indicated that formulations of BN-Nps with negative zeta potential were found to be effective compared to chitosan-coated BN-Nps with high positive zeta potential. These findings emphasize the future availability of BN-Nps formulation providing antibacterial activity.

Keywords

antibacterial activity boron nitride chitosan nanoparticles zeta potential DELIVERY-SYSTEMS NITRIDE NANOTUBES CELLULAR UPTAKE ANTIBACTERIAL DRUG NANOPRECIPITATION BIOCOMPATIBILITY NANOFIBERS TOXICITY SURFACES

WoS Categories

Polymer Science

Citation

Journal: POLYMER-KOREA
Year: 2022
Volume: 46
Issue: 6
Pages: 709-721
ISSN: 0379-153X
eISSN: 2234-8077
DOI: 10.7317/pk.2022.46.6.709
WoS UID: WOS:000883750600001

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