Article 2022 · 0 citations

Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

Colluoglu, Cagdas, Balci, Serdar, Gundogdu, Betul, Coban, Taha Abdulkadir, Bulut, Seval, Suleyman, Halis

Abstract

This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examinations were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.

Keywords

TOXICITY STRESS ANTIOXIDANTS GLUTATHIONE INFERTILITY EXTRACT TISSUE OXYGEN ACID

WoS Categories

Pharmacology & Pharmacy

Sustainable Development Goals

Gender Equality Good Health and Well-being

Citation

Journal: BANGLADESH JOURNAL OF PHARMACOLOGY
Year: 2022
Volume: 17
Issue: 3
Pages: 72-78
ISSN: 1991-007X
eISSN: 1991-0088
DOI: 10.3329/bjp.v17i3.59418
WoS UID: WOS:000883332100002

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