Isolation of Some Phenolic Compounds from <i>Plantago subulata</i> L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity

In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe3+ and Cu2+ reductive ability and Fe2+ chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCA I and hCA II), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and alpha-glycosidase (alpha-gly). K-i values were found these compounds in range of 0.24 +/- 0.05-1.38 +/- 0.34 mu M against hCA I, 0.194 +/- 0.018-1.03 +/- 0.06 mu M against hCA II, 0.043 +/- 0.01-0.154 +/- 0.02 mu M against AChE, 3.92 +/- 1.08-11.93 +/- 4.45 mu M against BChE, 0.082 +/- 0.0008-1.68 +/- 0.42 mu M against AR, and 6.93 +/- 2.74-17.17 +/- 6.70 mu M against alpha-glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.

Journal

CHEMISTRY & BIODIVERSITY

Year

2022

Volume

19

Issue

8

ISSN

1612-1872

eISSN

1612-1880

DOI

10.1002/cbdv.202200280

WoS UID

WOS:000821529400001