Article 2022 · 5 citations

EFFECT OF LUTEIN ON OXIDANTS AND PROINFLAMMATORY CYTOKINE-RELATED LIVER ISCHEMIA-REPERFUSION INJURY

Gundogdu, Betul, Tas, Hakan Gokalp, Suleyman, Bahadir, Mamedov, Renad, Yuce, Neslihan, Kuyrukluyildiz, Ufuk, Suleyman, Halis

Abstract

Lutein has an anti-inflammatory impact on tissues, according to recent research. The goal of our research was to see how lutein affected the biochemical and histological results of ischemia-reperfusion (I/R) intervention on rats??? livers. A total of 18 rats were divided into a sham operation group (HG), a liver I/R (KIR) group, or lutein (1mg/kg)+liver I/R (LIR) groups. Biochemical measures and histological exams were done in all three groups after I/R intervention. MDA, NF-??B, TNF-??, IL-1, ALT, and AST levels were significantly higher (p < 0.001) in the KIR group compared to the HG and LIR groups, although tGSH was significantly lower (p < 0.001). The HG group was histopathologically normal. The KIR group had severe degeneration, necrosis, and inflammation in the portal area and parenchyma. The LIR group had mild inflammation in the portal area and parenchyma. The use of lutein might be an alternative treatment for liver damage caused by I/R responses during surgery.

Keywords

oxidative stress lutein liver ischemia reperfusion NEUROPATHIC PAIN OXIDATIVE STRESS RATS ZEAXANTHIN MODULATOR DAMAGE

WoS Categories

Pharmacology & Pharmacy

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ACTA POLONIAE PHARMACEUTICA
Year: 2022
Volume: 79
Issue: 1
Pages: 129-135
ISSN: 0001-6837
eISSN: 2353-5288
DOI: 10.32383/appdr/147645
WoS UID: WOS:000798596300014

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