Article 2022 · 3 citations

Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters

Abstract

Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sodium-Amp.Na) were successfully prepared using different polymers by the lyophilization technique. This study aims to prepare and characterize floating lyophilized tablets to understand the effect of different biopolymers on quality control parameters more clearly. Within the scope of characterization studies, many parameters were evaluated successfully. All tablets showed 24-hour release and had a mesoporous structure, as understood from the Brunauer-Emmett-Teller (BET) analysis. It has been determined from the Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses that Amp.Na doesn't interact with excipients and is an amorphous form. These formulations can be used for other drugs in the future, and optimum properties can be easily characterized.

Keywords

floating tablet lyophilization polymers release kinetics Brunauer-Emmett-Teller Fourier transform infrared X-ray diffraction DRUG-DELIVERY SYSTEMS IN-VITRO EVALUATION POROUS MATRIX FORMULATION OPTIMIZATION AMPICILLIN CELLULOSE ALGINATE DESIGN

WoS Categories

Polymer Science

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: POLYMER-KOREA
Year: 2022
Volume: 46
Issue: 2
Pages: 145-158
ISSN: 0379-153X
eISSN: 2234-8077
DOI: 10.7317/pk.2022.46.2.145
WoS UID: WOS:000790393400001

Open via DOI