Article 2023 · 15 citations

Determinants of Leaky Gut and Gut Microbiota Differences in Children With Autism Spectrum Disorder and Their Siblings

Yitik Tonkaz, Gulsum, Esin, Ibrahim Selcuk, Turan, Bahadir, Uslu, Hakan, Dursun, Onur Burak

Abstract

Leaky gut hypothesis is one of the well-known theory which tries to explain etiology of Autism Spectrum Disorder (ASD). Unfortunately there is still a gap of evidence to investigate the corner points of the hypothesis. The aim of this study was to investigate the determinants of leaky gut in children with ASD, their siblings and healthy controls. Intestinal microbiota was found to be similar between ASD and sibling groups. Biological markers of bacterial translocation showed a significant difference in the sibling group, whereas the marker indicating local inflammation was not different between the groups. The findings from this study did not support the role of Gut microbiota or leaky gut on the etiology of autism.

Keywords

Autism microbiota LBP s-CD14 Fecal calprotectin REAL-TIME PCR CASEIN-FREE DIET FECAL CALPROTECTIN GLUTEN-FREE GASTROINTESTINAL DYSFUNCTION SOLUBLE CD14 INFLAMMATION BEHAVIOR DISEASE FECES

WoS Categories

Psychology, Developmental

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Year: 2023
Volume: 53
Issue: 7
Pages: 2703-2716
ISSN: 0162-3257
eISSN: 1573-3432
DOI: 10.1007/s10803-022-05540-z
WoS UID: WOS:000784866500004

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