Article 2021 · 4 citations

Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study

Yaman, Mehmet Emrah, Avci, Izzet, Atila, Nihal Efe, Atila, Alptug, Kayili, Haci Mehmet, Salih, Bekir

Abstract

Seasonal allergic rhinitis (SAR) is an inflammatory process. In this pilot study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted to investigate the effects of SAR on serum N-glycome in a small dataset (n = 10 for both SAR patients and controls). It was detected that two N-glycan compositions (H6N5E2L1 and H6N5E1L2) were down-regulated in SAR patients. Additionally, five tri-antennary N-glycan traits, including both galactosylated and sialylated (A3GS and A3GL) and non-fucosylated (A3F0GE, A3F0GL, A3F0GS) ones, were decreased. Furthermore, three high-antennary and fucosylated N-glycan traits (A3F, A3EF and A4F) were increased in SAR patients compared to controls.

Keywords

Glycomics MALDI-TOF-MS mass spectrometry seasonal Allergic rhinitis (SAR) serum N-glycosylation SIALIC ACIDS GLYCOSYLATION GLYCAN CANCER LYMPHOCYTES HEALTH TOOL

WoS Categories

Biochemistry & Molecular Biology Chemistry, Organic

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF CARBOHYDRATE CHEMISTRY
Year: 2021
Volume: 40
Issue: 6
Pages: 269-282
ISSN: 0732-8303
eISSN: 1532-2327
DOI: 10.1080/07328303.2021.2009502
WoS UID: WOS:000725432500001

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