Article 2021 · 54 citations

Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan-induced paw edema in rats

Semis, Halil Sezgin, Gur, Cihan, Ileriturk, Mustafa, Kaynar, Ozgur, Kandemir, Fatih Mehmet

Abstract

In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference.

Keywords

lambda-Carrageenan caffeic acid phenethyl ester cyclooxygenase-2 inflammation paw edema NF-KAPPA-B PRO-INFLAMMATORY MEDIATORS OXIDATIVE STRESS ICAM-1 EXPRESSION APOPTOSIS BRAIN TOXICITY MACROPHAGES INDUCTION PATHWAYS

WoS Categories

Toxicology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: HUMAN & EXPERIMENTAL TOXICOLOGY
Year: 2021
Volume: 40
Issue: 12_SUPPL
Pages: S721-S738
ISSN: 0960-3271
eISSN: 1477-0903
DOI: 10.1177/09603271211054436
WoS UID: WOS:000721351200001

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