Novel tetrakis-phthalocyanines bearing pyrimidine derivative: crystal XRD analysis, enzyme inhibition, molecular docking, and anticancer effects

In this study, the novel 4-(4-Aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its 3D structure was verified by the single crystal X-ray diffraction experiment. Then, its peripherally tetra-substituted phthalocyanines (2,3) and the methylated derivatives (2a,3a) containing pyrimidine derivative were synthesized. All these newly synthesized compounds were characterized with various spectroscopic methods such as UV-Vis, FT-IR, H-1-NMR, C-13-NMR and MALDI-TOF MS by obtaining satisfactory results. In addition, these novel phthalocyanines effectively inhibited acetylcholinesterase enzyme, with K-i values in the range of 10.43 +/- 2.38 to 41.70 +/- 9.32 mu M. For the related enzyme, the IC50 values were obtained in the range of 11.68 to 44.28 mu M. For alpha-glycosidase enzyme the most effective K-i values of (3a) and (2) were with K-i values of 92.87 +/- 10.70 and 95.18 +/- 17.83 mu M, respectively. Indeed, the most potent phthalocyanines against both enzymes were recorded for the purpose of investigating interaction modes of these complexes in the active site of the target enzyme. The cytotoxicity potential of these phthalocyanines against human breast, colon, and prostate cancers demonstrated that these compounds had normal cytotoxic effects. Communicated by Ramaswamy H. Sarma

Journal

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Year

2023

Volume

41

Issue

1

Pages

249-262

ISSN

0739-1102

eISSN

1538-0254

DOI

10.1080/07391102.2021.2004923

WoS UID

WOS:000721173300001