The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib
Yilmaz, Ali, Simsek, Melih, Hannarici, Zekeriya, Buyukbayram, Mehmet E., Bilici, Mehmet, Tekin, Salim B.
Aim: To show the prognostic significance of the glucose-to-lymphocyte ratio (GLR) in hepatocellular carcinoma (HCC). Patients & methods: A total of 150 patients with advanced HCC who were treated with sorafenib in our center between January 2011 and December 2019 were included in the study retrospectively. Neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index and GLR were analyzed to assess their prognostic value using Kaplan-Meier and Cox regression analysis before and after propensity score matching (PSM). Results: In univariate analysis before and after PSM, albumin-bilirubin grade, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, prognostic nutritional index, AFP level and GLR were found to be significantly associated with both progression-free and overall survival. In multivariate analysis before and after PSM, GLR, albumin-bilirubin grade and AFP were determined to be independent prognostic factors for progression-free and overall survival. Conclusion: The GLR prior to sorafenib treatment is a new prognostic biomarker that may predict survival in advanced HCC.
- Journal
- FUTURE ONCOLOGY
- Year
- 2021
- Volume
- 17
- Issue
- 33
- Pages
- 4545-4559
- ISSN
- 1479-6694
- eISSN
- 1744-8301
- DOI
- 10.2217/fon-2021-0457
- WoS UID
- WOS:000688118300001