Article 2022 · 98 citations

Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

Demir, Yeliz, Ceylan, Hamid, Turkes, Cuneyt, Beydemir, Sukru

Abstract

Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. These enzymes inhibition could be essential to prevent diabetic complications. AR and SDH enzymes were purified from sheep kidney. Then, VA, CA and UA were tested in various concentrations against these enzymes activity in vitro. KI values were found to be as 1.46 +/- 0.04, 5.13 +/- 0.25 and 11.71 +/- 0.27 lM for VA, CA and UA, respectively, for AR. KI constants were found to be as 15.32 +/- 0.34, 145.60 +/- 2.17 and 213.40 +/- 2.64 lM VA, CA and UA, respectively, for SDH. These findings indicate that VA, CA and UA could be useful in the treatment of diabetic complications.

Keywords

Aldose reductase sorbitol dehydrogenase carnosic acid usnic acid vulpinic acid IN-SILICO EVALUATION CARBONIC-ANHYDRASE POTENTIAL ACETYLCHOLINESTERASE VITRO HYDROCHLORIDE DERIVATIVES GLYCATION INSIGHT DRUGS CELLS

WoS Categories

Biochemistry & Molecular Biology Biophysics

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Year: 2022
Volume: 40
Issue: 22
Pages: 12008-12021
ISSN: 0739-1102
eISSN: 1538-0254
DOI: 10.1080/07391102.2021.1967195
WoS UID: WOS:000687604400001

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