Article 2021 · 20 citations

Effects of <i>Achillea millefolium</i> on cisplatin induced ocular toxicity: an experimental study

Okkay, Ufuk, Ferah Okkay, Irmak, Aydin, Ismail Cagri, Bayram, Cemil, Ertugrul, Muhammed Sait, Gezer, Arzu, Hacimuftuoglu, Ahmet

Abstract

Aim: Cisplatin is a widely used and highly effective anti-cancer agent and one of the limiting side effects of cisplatin is ocular toxicity. Achillea millefolium, also known as yarrow, is a plant that has been used for many years to treat various health problems including chemotherapy-related toxicities. Methods: The present investigation was designed to evaluate the biochemical, molecular and histopathological effects of Achillea Millefolium on cisplatin-induced oxidative and inflammatory ocular damage in rats. Twenty-four adult male rats were assigned randomly to four groups (n = 6) as (1) control, (2) cisplatin (7 mg/kg, intraperitoneally), (3) Cisplatin + Achillea millefolium (200 mg/kg, orally for 14 consecutive days), (4) Cisplatin + Achillea millefolium (400 mg/kg, orally for 14 consecutive days). Levels of total antioxidant capacity and total oxidant status, SOD, MDA, IL-1 beta, and IL-10 were measured in ocular tissue. The mRNA expressions of TNF-alpha, nuclear factor kappa B and Caspase-3 were evaluated. Also, ocular sections were evaluated histopathologically. Results: Achillea Millefolium upregulated ocular antioxidant enzymes and downregulated inflammation. The SOD activity and total antioxidant capacity increased whereas total oxidant status and MDA levels decreased significantly at high dose group. High dose Achillea millefolium treatment reduced the IL-1 beta concentrations, whereas IL-10 levels increased significantly in that group. Moreover, we observed that Achillea millefolium restored ocular histopathological structure and significantly suppressed apoptosis by reducing the expression of Caspase-3. Conclusion: Collectively, our results suggest that Achillea millefolium have protective effects against cisplatin-induced ocular toxicity and is a promising adjuvant therapy with the potential to prevent cisplatin related ocular toxicity.

Keywords

Achillea millefolium cisplatin ocular toxicity rat oxidative stress inflammation apoptosis OXIDATIVE STRESS ANTIMICROBIAL ACTIVITY INDUCED NEPHROTOXICITY GENE-EXPRESSION ESSENTIAL OIL NITRIC-OXIDE L. EXTRACT ANTIOXIDANT INFLAMMATION

WoS Categories

Ophthalmology Toxicology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: CUTANEOUS AND OCULAR TOXICOLOGY
Year: 2021
Volume: 40
Issue: 3
Pages: 214-220
ISSN: 1556-9527
eISSN: 1556-9535
DOI: 10.1080/15569527.2021.1919137
WoS UID: WOS:000667538700001

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