Article 2021 · 5 citations

Preparation of a <SUP>99m</SUP>Tc-labeled graft polymer and its in vitro and in vivo evaluation

Avcibasi, Ugur, Turkyarar, Taner, Karadag, Aysegul, Bakan, Buket, Yavasoglu, Nefise Ulku Karabay, Kusat, Kevser, Akgol, Sinan, Gulcemal, Derya, Tekin, Volkan, Muftuler, Fazilet Zumrut Biber, Topal, Gokcen, Parlak, Yasemin, Gumuser, Fikriye Gul

Abstract

The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.

Keywords

Nanopolymer Graft Polymer Cytotoxicity Tc-99m Radiolabeling Proline MAGNETIC NANOPARTICLES TOXICITY BIODISTRIBUTION CYTOTOXICITY ADSORPTION DELIVERY PROLINE THERAPY FUTURE SIZE

WoS Categories

Chemistry, Analytical Chemistry, Inorganic & Nuclear Nuclear Science & Technology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Year: 2021
Volume: 329
Issue: 2
Pages: 511-525
ISSN: 0236-5731
eISSN: 1588-2780
DOI: 10.1007/s10967-021-07817-6
WoS UID: WOS:000664014000004

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