Article
2021
·
14 citations
Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-<i>a</i>]pyridines with <i>para</i>-Quinone Methides
Abstract
Metal- and additive-free C3-alkylation of imidazo[1,2-a]pyridines with para-quinone methides (p-QMs) has been realized. 1,6-Nucleophilic addition of imidazopyridines to p-QMs were carried out under mild conditions in very excellent yields. Furthermore, we performed late-stage drug functionalization for zolimidine. All transformations proceeded with broad substrate scope and good functional group tolerance.
Keywords
Imidazo[1
2-a]pyridine
HFIP
para-quinone methide
zolimidine
1
6-nucleophilic addition
1,6-CONJUGATE ADDITION
CATALYST
EFFICIENT
ACCESS
WoS Categories
Chemistry, Organic
Citation
- Journal
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Year
- 2021
- Volume
- 10
- Issue
- 7
- Pages
- 1814-1821
- ISSN
- 2193-5807
- eISSN
- 2193-5815
- DOI
- 10.1002/ajoc.202100313
- WoS UID
- WOS:000659718200001