Article 2021 · 68 citations

Anticholinergic, Antidiabetic and Antioxidant Activities of <i>Ferula orientalis</i> L. Determination of Its Polyphenol Contents by LC-HRMS

Kiziltas, Hatice, Goren, Ahmet C., Bingol, Zeynebe, Alwasel, Saleh H., Gulcin, Ilhami

Abstract

To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS(center dot+) scavenging activity, DPPH. scavenging activity, Fe(3+)reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, alpha-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 mu g/mL against acetylcholinesterase (AChE), 0.815 mu g/mL against alpha-glycosidase, and 0.675 mu g/mL against alpha-amylase.

Keywords

Ferula orientalis alpha-glycosidase antioxidant activity phenolic compound acetylcholinesterase alpha-amylase IN-VITRO ANTIOXIDANT LYOPHILIZED AQUEOUS EXTRACT ALPHA-AMYLASE ACETYLCHOLINESTERASE INHIBITORS DERIVATIVES MS/MS VULGARIS DOCKING LEAVES

WoS Categories

Plant Sciences Chemistry, Applied Chemistry, Medicinal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: RECORDS OF NATURAL PRODUCTS
Year: 2021
Volume: 15
Issue: 6
Pages: 513-528
ISSN: 1307-6167
DOI: 10.25135/rnp.236.21.02.1983
WoS UID: WOS:000658306500008

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