The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice
Gelen, Volkan, Sengul, Emin, Yildirim, Serkan, Senturk, Esra, Tekin, Samet, Kukurt, Abdulsamed
Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Application of 5-FU resulted in severe histopathological changes and severe renal failure with increased serum urea and creatinine levels. Also, 5-FU-induced kidney damage, increased levels of malondialdehyde (MDA), decreased superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activity, and glutathione (GSH) level have been demonstrated. Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. However, especially high doses of hesperidin and curcumin treatment significantly improved 5-FU-induced oxidative stress/lipid peroxidation, apoptosis/DNA damage, and renal dysfunction. Based on these data, our results suggest that hesperidin and curcumin may be used as new and promising agents against 5-FU-induced nephrotoxicity.
- Journal
- ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Year
- 2021
- Volume
- 28
- Issue
- 34
- Pages
- 47046-47055
- ISSN
- 0944-1344
- eISSN
- 1614-7499
- DOI
- 10.1007/s11356-021-13969-5
- WoS UID
- WOS:000642398900016