Synthesis of bis(benzoxazole) frameworks chiralized by planar chiral [2.2]Paracyclophane

In this study, a new class of chiral bis(benzoxazole) has been synthesized. The bis(benzoxazole) framework, which has an achiral structure was chiralized by a planar chiral [2.2]paracyclophane moiety. Both enantiomeric forms of the bis(benzoxazole) derivatives were successfully obtained in 99% ee. Even though the starting material was not completely enantiomerically pure, enantiomeric enrichment was afforded by the Horeau principle in the synthesis route. (C) 2021 Elsevier Ltd. All rights reserved.

Journal

TETRAHEDRON LETTERS

Year

2021

Volume

67

ISSN

0040-4039

eISSN

1873-3581

DOI

10.1016/j.tetlet.2021.152871

WoS UID

WOS:000626511700024