Article 2021 · 18 citations

Protective effect of luteolin on acute lung injury in a rat model of sepsis

Celebi, Demet, Aydin, Pelin, Cinar, Irfan, Kutlu, Zerrin, Calik, Ilknur, Halici, Zekai, Bilici, Dilek, Bayraktutan, Zafer

Abstract

We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-alpha and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties.

Keywords

Antioxidants cecal ligation IL-10 inflammation luteolin rat sepsis TNF-alpha CECAL LIGATION LIPOPOLYSACCHARIDE INFLAMMATION QUERCETIN TARGET ASSAY ACID

WoS Categories

Biotechnology & Applied Microbiology Cell Biology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: BIOTECHNIC & HISTOCHEMISTRY
Year: 2021
Volume: 96
Issue: 8
Pages: 579-585
ISSN: 1052-0295
eISSN: 1473-7760
DOI: 10.1080/10520295.2020.1846787
WoS UID: WOS:000588516300001

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