The targets of β-sitosterol as a novel therapeutic against cardio-renal complications in acute renal ischemia/reperfusion damage
Koc, Kubra, Geyikoglu, Fatime, Cakmak, Ozge, Koca, Aynur, Kutlu, Zerrin, Aysin, Ferhunde, Yilmaz, Asli, Askin, Hakan
This research is the first to use beta-sitosterol on myocardial and renal tissues in renal ischemia/reperfusion (IR) damage. Female Wistar rats were randomly divided into three groups: control (sham), renal IR (50 min ischemia - 3 h reperfusion), and renal IR + 150 mg/kg/p.o. beta-sitosterol (the rats were treated with beta-sitosterol orally once 1 h before the IR procedure). beta-Sitosterol pretreatment caused an increase in superoxide dismutase and glutathione activities and a decrease in malondialdehyde levels in the kidney and heart. Moreover, it alleviated histopathological changes and downregulated the levels of tumor necrosis factor-alpha and interleukin-6 and upregulated the levels of endothelial nitric oxide synthase. As conclusion, the potential of beta-sitosterol for renal and cardiac necrosis and apoptosis appears to act by limiting inflammatory response and oxidative stress. Thus, the potential of this compound is noteworthy and may serve as a potential therapeutic in the treatment of acute organ damages due to renal IR.
- Journal
- NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Year
- 2021
- Volume
- 394
- Issue
- 3
- Pages
- 469-479
- ISSN
- 0028-1298
- eISSN
- 1432-1912
- DOI
- 10.1007/s00210-020-01984-1
- WoS UID
- WOS:000577575600001