Article 2022 · 4 citations

Can zaprinast and avanafil induce the levels of angiogenesis, bone morphogenic protein 2, 4 and 7 in kidney of ovariectomised rats?

Huyut, Zubeyir, Bakan, Nuri, Yildirim, Serkan, Akbay, Halil Ibrahim, Huyut, Mehmet Tahir, Ahlatci, Adem, Ucar, Bunyamin

Abstract

Objective: This study investigated effects of zaprinast and avanafil on angiogenesis, vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 2, 4 and 7. Methods: Female rats were randomly divided into four groups (n = 6). Sham; abdomen was approximately 2 cm opened and closed. Ovariectomised (OVX); abdomen was opened 2 cm and the ovaries were cut. OVX + zaprinast and OVX + avanafil groups; after the same procedure with OVX, 10 mg/kg zaprinast and avanafil were orally administered for 2 month, respectively. Angiogenesis and the levels of VEGF, BMP2, 4 and 7 were determined. Results: VEGF, BMP2, 4 and 7 levels in OVX + zaprinast and especially OVX + avanafil groups were higher than the sham and OVX (p < .05). However, only VEGF and BMP2 levels in OVX + zaprinast group were significant according to sham (p < .05). Also, angiogenesis in OVX + zaprinast and OVX + avanafil groups was dominant according to sham and OVX (p < .05). Conclusions: Zaprinast and avanafil induced BMP2, 4 and 7 levels synergistically with increased VEGF and angiogenesis in renal tissue.

Keywords

Angiogenesis avanafil phosphodiesterase-5 inhibitor bone morphogenetic protein zaprinast ENDOTHELIAL GROWTH-FACTOR OXIDATIVE DAMAGE INHIBITORS BMP-2 VEGF

WoS Categories

Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Year: 2022
Volume: 128
Issue: 4
Pages: 945-950
ISSN: 1381-3455
eISSN: 1744-4160
DOI: 10.1080/13813455.2020.1740743
WoS UID: WOS:000523966900001

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