Article 2021 · 31 citations

The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats

Karaca, Aysegul, Yilmaz, Seval, Kaya, Emre, Altun, Serdar

Abstract

Oxidative damage caused by aflatoxin (AF) in rat liver tissue and the inhibition effect of lycopene against this injury was investigated. Groups were formed as; control group (not treated), lycopene group (5 mg/kg/day, gavage for 15 days), AFB1 group (0.5 mg/kg/day, gavage for 7 days) and AFB1 + lycopene group. Lycopene administered simultaneously with AFB1. It was observed significant increase in malondialdehyde level, decrease in glutathione level, antioxidant enzyme activities in liver tissue of AFB1 group when compared with control group. It was determined to significantly increase in plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities in AFB1 group when compared with control group. It was determined significant decrease in malondialdehyde level, plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities and increase in glutathione level, antioxidant enzyme activities in AFB1 + lycopene group when compared with AFB1 group. This study suggests that lycopene which has antioxidant properties can be prevented from AFB1 induced hepatotoxicity.

Keywords

Aflatoxin antioxidant enzyme glutathione lycopene malondialdehyde GLUTATHIONE-S-TRANSFERASE OXIDATIVE STRESS B-1 METABOLISM INJURY LIVER INVOLVEMENT PARAMETERS DAMAGE MICE

WoS Categories

Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology

Citation

Journal: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Year: 2021
Volume: 127
Issue: 5
Pages: 429-436
ISSN: 1381-3455
eISSN: 1744-4160
DOI: 10.1080/13813455.2019.1648516
WoS UID: WOS:000479159500001

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