Article 2021 · 34 citations

Protective effects of gallic acid on doxorubicin-induced cardiotoxicity; an experimantal study

Akdemir, Fazile Nur Ekinci, Yildirim, Serkan, Kandemir, Fatih Mehmet, Tanyeli, Ayhan, Kucukler, Sefa, Dortbudak, Muhammed Bahaeddin

Abstract

The present study aims to examine the possible beneficial effects of gallic acid (GA) against doxorubicin-induced cardiotoxicity in the experimental model. Rats were weighed and divided into groups. Groups as following; control, gallic acid (GA), doxorubicin (DOX) and GA + DOX groups. At the end of the experiment, rats were sacrificed and heart tissue removed. The tissues were analysed in terms of biochemical (MDA, SOD, CAT, GSH, GPx), pathological (hyaline degeneration, Zenkerin necrosis, hyperaemia) and immunohistochemical (TNF-alpha, Cox-2). MDA level decreased and antioxidant enzyme activities increased in GA + DOX group compared to doxorubicin group. TNF-alpha, Cox-2 expression levels were severe in the DOX group. Also, pathologic tissue damage in heart tissue increased due to doxorubicin. Additionally, pathologic tissue damage and TNF-alpha, Cox-2 expression levels decreased in GA + DOX group. According to our findings, GA has protective effect against doxorubicin-induced cardiotoxicity.

Keywords

Doxorubicin gallic acid cardiotoxicity antioxidant cytokins rat ADRIAMYCIN-INDUCED CARDIOMYOPATHY OXIDATIVE STRESS INDUCED APOPTOSIS LIVER-DAMAGE TNF-ALPHA CYCLOOXYGENASE-2 ANTIOXIDANTS INHIBITION DIOSCIN INJURY

WoS Categories

Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Year: 2021
Volume: 127
Issue: 3
Pages: 258-265
ISSN: 1381-3455
eISSN: 1744-4160
DOI: 10.1080/13813455.2019.1630652
WoS UID: WOS:000475144500001

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