Evaluation of the Relationship between Nitric Oxide Levels and Troponin, CK, CK-Mb, and CoHB Levels in Patients Presenting to the Emergency Department with Carbon Monoxide Poisoning
Aim: Ischemic alterations may occur due to hypoxia following carbon monoxide (CO) poisoning. As a result, the heart, brain, and other organs experience a loss of functionality. This study aimed to evaluate the relationship between the levels of nitric oxide (NO), which may be responsible for cardiac damage, and those of troponin, creatine kinase muscle-brain (CK-MB), and carboxyhemoglobin (COHb). These are markers of cardiac damage in patients who presented to the emergency department after being exposed to CO gas. Materials and Methods: This prospective study included 103 individuals divided into three groups: troponin-negative patients with CO poisoning, troponin-positive patients with CO poisoning, and healthy controls. The NO levels of the groups were statistically compared. The correlation between NO levels and troponin, creatine kinase (CK), CK-MB, and COHb levels was also examined. Results: The NO value was the lowest in the troponin-positive group and the highest in the control group, with significant differences between the three groups (p<0.001). According to the correlation analysis, the NO level was significantly and negatively correlated with the CK and COHb levels, but not the CK-MB level (p<0.001). This study revealed lower NO levels in patients with CO poisoning than in healthy individuals. Conclusions: NO levels have an inverse relationship with troponin and CK values when comparing groups categorized by troponin levels. Therefore, it is postulated that cardiac damage can be prevented by administering inhaler NO therapy together with CO therapy to patients with CO poisoning.
- Dergi
- EURASIAN JOURNAL OF EMERGENCY MEDICINE
- Yıl
- 2026
- Cilt
- 25
- Sayı
- 1
- Sayfa
- 8-14
- ISSN
- 2149-5807
- eISSN
- 2149-6048
- DOI
- 10.4274/eajem.galenos.2025.04875
- WoS UID
- WOS:001683496600001