Article 2026 · 0 atıf

Anticancer Properties of Newly Synthesized Pyrrole Derivatives as Potential Tyrosine Kinase Inhibitors

Kaya, Meltem, Kara, Yunus, Sanli-Mohamed, Gulsah

Özet

The anticancer activity of a series of newly synthesized pyrrole derivatives was systematically evaluated in HeLa cervical cancer cells, focusing on their potential as tyrosine kinase inhibitors and modulators of the mTOR signaling pathway. This study builds on our previous synthetic work by investigating the biological effects of seven structurally characterized compounds (d1-d7). Among them, compounds d1 and d3 exhibited the most potent cytotoxicity, with IC50 values of 140.6 mu M and 366.4 mu M, respectively, after 48 h of treatment. Both compounds significantly impaired cell cycle progression-d1 induced S-phase arrest, while d3 caused G1-phase arrest-and markedly suppressed cell migration in wound healing assays. Mechanistically, these effects were accompanied by reduced phosphorylation of p70S6K (Thr389, Ser421/424) and increased p-4EBP1, indicating inhibition of mTORC1 signaling. These findings suggest that d1 and d3 are promising lead compounds with dual antiproliferative and anti-migratory activity in cervical cancer, mediated through modulation of the PI3K/Akt/mTOR axis.

Anahtar Kelimeler

cell cycle arrest. mTOR pathway HeLa cells pyrrole derivatives tyrosine kinase inhibitors HUMAN-PAPILLOMAVIRUS GROWTH ASSAY SURVIVAL

WoS Kategorileri

Biochemistry & Molecular Biology Toxicology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Yıl: 2026
Cilt: 40
Sayı: 2
ISSN: 1095-6670
eISSN: 1099-0461
DOI: 10.1002/jbt.70665
WoS UID: WOS:001681004000001

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