Review 2025 · 0 atıf

Tiny packages, big potential: bacterial membrane vesicles in vaccinology

Varol, Ayse, Aydin, Seyma, Adiguzel, Ahmet, Ozdemir, Selcuk

Özet

Bacterial membrane vesicles (BMVs) are nanoscale, bilayered proteolipid structures secreted by both Gramnegative and Gram-positive bacteria. Initially considered cellular debris, BMVs are now recognized as evolutionarily conserved entities with critical roles in bacterial communication, immune modulation, virulence factor delivery, and horizontal gene transfer. Their structural and functional resemblance to eukaryotic extracellular vesicles has fueled growing interest in their use as versatile vaccine platforms. Licensed meningococcal OMV vaccines established proof-of-concept for their safety and immunogenicity, and ongoing studies are extending applications to enteric pathogens and viral infections. Recent advances in genetic engineering, glycoengineering, and modular antigen display systems have enabled the design of "plug-and-play" BMVs with reduced reactogenicity and enhanced protective efficacy. In parallel, innovations in bioprocessing and formulation technologies are improving scalability, stability, and delivery, including mucosal routes. This review highlights the immunological properties, translational potential, and key challenges of BMV-based vaccines, with an emphasis on strategies to optimize safety, antigen specificity, and manufacturing for next-generation vaccine development.

Anahtar Kelimeler

Next-generation vaccines Bacterial membrane vesicles Outer membrane vesicles Translational vaccinology Vaccine platforms SEROGROUP-B DISEASE SHIGELLA-FLEXNERI VIRULENCE FACTORS LOCAL MUCOSAL TAILOR-MADE MODULATION EPIDEMIC ASSOCIATION BIOGENESIS PROTECTION

WoS Kategorileri

Biotechnology & Applied Microbiology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: MICROBIAL CELL FACTORIES
Yıl: 2025
Cilt: 25
Sayı: 1
eISSN: 1475-2859
DOI: 10.1186/s12934-025-02908-5
WoS UID: WOS:001676437600001

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