Article 2026 · 0 atıf

Epigallocatechin-3-Gallate Provides Hepatoprotection Through Endoplasmic Reticulum Stress/TXNIP/NLRP3 Axis in Paracetamol-Induced Acute Liver Injury

Demirtas, Nagihan, Mazlumoglu, Busra Sahin, Celep, Nevra Aydemir, Cadirci, Elif, Halici, Zekai, Palabiyik-Yucelik, Saziye Sezin

Özet

Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound with strong antioxidant properties and is abundantly found in green tea. We investigated how EGCG affects the liver injury of high-dose paracetamol in this study. In our study, 56 rats were divided into seven groups (n = 8): healthy control, EGCG (100 mg/kg), paracetamol (2 g/kg), paracetamol + EGCG 25 (2 g/kg + 25 mg/kg), paracetamol + EGCG 50 (2 g/kg + 50 mg/kg), paracetamol + EGCG 100 (2 g/kg + 100 mg/kg) and paracetamol + N-acetyl cysteine (NAC, 2 g/kg + 140 mg/kg). Our findings suggest that high-dose paracetamol induces liver injury through endoplasmic reticulum (ER) stress and that EGCG alleviates liver injury by attenuating ER stress-induced inflammasome signalling.

Anahtar Kelimeler

(-)-epigallocatechin-3-gallate (EGCG) endoplasmic reticulum stress inflammasome liver paracetamol INDUCED HEPATOTOXICITY MODEL OXIDATIVE STRESS PROTECTS MICE ER STRESS INHIBITION MECHANISM TOXICITY ASSAY EGCG

WoS Kategorileri

Pharmacology & Pharmacy Toxicology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Yıl: 2026
Cilt: 138
Sayı: 1
ISSN: 1742-7835
eISSN: 1742-7843
DOI: 10.1111/bcpt.70155
WoS UID: WOS:001645402300014

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