Synthetic strategies for aminocyclitols: An updated review

In this review, we report on recent synthetic methodologies for aminocyclitols, which are formally derived from cyclitols, mainly containing a trihydroxy aminocycloalkane core that can be found the common scaffold in several families of natural products. Among them, the aminoglycoside antibiotics such as streptomycin, dihydrostreptomycin, kanamycin, gentamicin, tobramycin, amikacin, and neomycin have emerged as particularly significant agents in antibacterial therapy. Moreover, certain aminocyclitols have been employed as key scaffolds for the design of potent glycosidase inhibitors, which hold broad utility in medicinal chemistry. Owing to their diverse biological activities, aminocyclitols have attracted considerable attention in the fields of organic and medicinal chemistry. Synthetic strategies focusing on selectivity, stereochemical control, and yield optimization have enabled the efficient the synthesis of a large variety of aminocyclitols. The literature covered in this review dates from December 2019 to January 2025.

Dergi

TETRAHEDRON

Yıl

2026

Cilt

189

ISSN

0040-4020

eISSN

1464-5416

DOI

10.1016/j.tet.2025.134988

WoS UID

WOS:001605888700001