Refractory Epidermolysis Bullosa Pruriginosa with Rapid Clinical Response to Upadacitinib Treatment

Epidermolysis bullosa pruriginosa (EBP) is a rare subtype of dystrophic EB. Topical corticosteroids, tacrolimus, oral thalidomide, and immunosuppressants are among the treatment options that can be given, but there is no consistently effective treatment. Some case reports have shown positive results in treatment with omalizumab, dupilumab, and Janus kinase inhibitors. We present a 37-year-old female EBP patient who had not responded to multiple previous treatments (systemic steroids, hydroxychloroquine, dapsone, omalizumab, and cyclosporine) but achieved a rapid clinical response to upadacitinib treatment. We are sharing our case to encourage the consideration of upadacitinib as an alternative treatment for refractory EBP cases.

Dergi

TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY

Yıl

2025

Cilt

19

Sayı

2

Sayfa

111-114

ISSN

1307-7635

eISSN

1308-5255

DOI

10.4274/tjd.galenos.2024.83803

WoS UID

WOS:001508380800001

Yayını aç (DOI)