Hemidiaphragmatic paralysis after ultrasound-guided brachial plexus blocks for shoulder surgery: A systematic review and meta-analysis of randomized clinical trials

Study objective: This review aimed to explore whether diaphragm-sparing regional techniques are more effective at preventing hemidiaphragm paralysis than conventional interscalene brachial plexus blockade (ISB) following shoulder surgery. Design: Systematic review of randomized clinical trials (RCTs) including meta-analyses, meta-regression, trial sequential analyses (TSA) and GRADE methodology. Setting: Online databases (Cochrane Library; MEDLINE; EMBASE; Scopus; Web of Science; and international trial registries) were searched for RCTs up to December 2022. Patients: Adult patients undergoing shoulder surgery following ultrasound-guided brachial plexus blockade, where incidence of hemidiaphragmatic paralysis was reported. Interventions: Diaphragm-sparing techniques following ultrasound-guided brachial plexus blockade were included: modifications of ISB (low-volume, extrafascial, and lower concentration); superior trunk block; supraclavicular brachial plexus block, infraclavicular brachial plexus block; costoclavicular brachial plexus block; and anterior and posterior approaches to the suprascapular nerve block. Measurements: The primary endpoint was the incidence of complete hemidiaphragmatic paralysis. Secondary endpoints included postoperative analgesia and safety-related outcomes. Main results: Twenty-eight RCTs involving 1737 subjects were identified. Of these, 22 were eligible for meta-analysis. Six regional techniques were analysed. The low-volume technique significantly reduced the incidence of hemidiaphragmatic paralysis as compared with the conventional ISB (risk ratio 0.62; 95 % CI 0.42 to 0.91; p = 0.02; absolute risk difference-0.30 [95 % CI-0.39 to-0.20]; I2 = 80 %) at short-term follow-up. TSA confirmed the results of this meta-analysis but did not reach the required sample size by 19.5 %, indicating that the result was not definitive. The combined infraclavicular-suprascapular blocks, the extrafascial technique, the lower concentration tech-nique, and the supraclavicular block reduced the incidence of hemidiaphragmatic paralysis by 97 %, 64 %, 57 % and 46 %, respectively. For the superior trunk block, TSA did not reach statistical significance. Conclusions: There is conclusive evidence that the extrafascial technique (high-level); lower concentration technique (moderate-level); and the supraclavicular blockade (low-level) are less detrimental to hemi-diaphragmatic paralysis than the conventional ISB. However, the results for other comparisons were not definitive. Systematic review protocol: PROSPERO CRD42022335056.

Dergi

JOURNAL OF CLINICAL ANESTHESIA

Yıl

2025

Cilt

105

ISSN

0952-8180

eISSN

1873-4529

DOI

10.1016/j.jclinane.2025.111874

WoS UID

WOS:001508160300001