Article 2025 · 0 atıf

Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

Uzuncakmak, Sevgi Karabulut, Ozcan, Halil, Aydin, Pelin, Halici, Zekai

Özet

Purpose: This study aims to investigate Lrig1 expression and to reveal the possible relationship between Lrig1, ERBB1 and ERBB2 in schizophrenia. Materials and Methods: In this study, peripheral blood samples of 70 schizophrenia patients and 60 healthy controls were used. Real Time PCR was applied for Lrig1, ERBB1 and ERBB2 gene expression analysis. Results: The level of Lrig1 mRNA was lower in the patients when compared to healthy controls. Expression levels of ERBB1 and ERBB2 were decreased in the patients versus in the healthy controls. According to the receiver operating characteristic curve analysis, the three genes had the power to discriminate the patients from the ERBB1 and ERBB2 expressions in the patients. in schizophrenia.

Anahtar Kelimeler

Schizophrenia Lrig1 ERBB1 ERBB2 EPIDERMAL-GROWTH-FACTOR RECEPTOR FAMILY SCALE RISK BETA

WoS Kategorileri

Medicine, General & Internal

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: CUKUROVA MEDICAL JOURNAL
Yıl: 2025
Cilt: 50
Sayı: 1
Sayfa: 221-230
ISSN: 2602-3032
eISSN: 2602-3040
DOI: 10.17826/cumj.1624159
WoS UID: WOS:001456063300023

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