Article 2025 · 0 atıf

Anti-Alzheimer, Antiglaucoma, and Antidiabetic Activities of Sainfoin (<i>Onobrychis buhseana</i> Boiss.)

Jafarova, Shahla, Aydin, Tuba, Isayev, Javanshir, Saglamtas, Ruya, Ozgokce, Fevzi, Kazaz, Cavit, Cakir, Ahmet

Özet

Onobrychis Adans. species, known as 'sainfoin,' are commercially valuable plants cultivated to produce high-protein animal feed. In this study, the ethanol extract of Onobrychis buhseana Boiss., which is widely distributed in Azerbaijan, was subjected to silica gel column and thin-layer chromatography for the first time, leading to the isolation of a new natural hydroquinone oligomer, named buhseanol (1), along with two known compounds, beta-arbutin (2) and an inositol derivative (3). The chemical structure of buhseanol (1) was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 NMR, Attached Proton Test NMR, and liquid chromatography-tandem mass spectrometry. Buhseanol (1), beta-arbutin (2), and the ethanol extract were evaluated for their anti-Alzheimer's, anti-glaucoma, and anti-diabetic effects, with both the extract and buhseanol (1) potentially showing these activities. The inositol derivative (3) did not exhibit any of these activities.

Anahtar Kelimeler

<italic>beta</italic>-arbutin buhseanol enzyme inhibition <italic>Onobrychis buhseana</italic> Boiss sainfoin ALPHA-GLUCOSIDASE CONDENSED TANNINS IDENTIFICATION

WoS Kategorileri

Biochemistry & Molecular Biology Chemistry, Multidisciplinary

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: CHEMISTRY & BIODIVERSITY
Yıl: 2025
Cilt: 22
Sayı: 7
ISSN: 1612-1872
eISSN: 1612-1880
DOI: 10.1002/cbdv.202402013
WoS UID: WOS:001432807500001

Yayını aç (DOI)