Synthesis of novel sulfamides derived from dopamine analogues with their<i> in</i><i> silico</i> studies against hyperprolactinemia

Because of the important biological properties of sulfamides, in the present work six novel sulfamides were synthesized from dopamine derivatives and their insilico studies were carried out against hyperprolactinemia. Five sulfamides were synthesized via the reaction of known dopamine derivatives with N,N-dimethyl sulfamoyl chloride in the presence of NEt3. For comparison of biological activity, a sulfamide without N-alkyl at the terminal nitrogen was also synthesized. For this synthesis, firstly benzyl alcohol was reacted with chlorosulfonyl isocyanate (CSI). Then, new sulfamoyl carbamate was obtained by the reaction of the formed carbamate derivative with a dopamine analogue in the presence of NEt3. As a result of the hydrogenolysis of the formed sulfamoyl carbamate under Pd-C catalyst, a new sulfamide was obtained. Molecular docking simulations and ADME predictions were employed to assess the binding affinity and drug-like properties of sulfamide derivatives at the dopamine D2 receptor, aiming to identify potential contributors to hyperprolactinemia. In the in silico docking studies, it was determined that the binding affinity of the R enantiomer of unsubstituted sulfamide 20 to the D2 receptor was higher than that of Cabergoline and Quinagolide used as standards and there was no deviation from the Lipinski rule of five in the ADME evaluation.

Dergi

ORGANIC COMMUNICATIONS

Yıl

2024

Cilt

17

Sayı

4

Sayfa

205-217

ISSN

1307-6175

DOI

10.25135/acg.oc.176.2411.3361

WoS UID

WOS:001391888200003