Article 2025 · 5 atıf

Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis

Bayir, Yasin, Erkayman, Beyzagul, Albayrak, Abdulmecit, Palabiyik-Yucelik, Saziye Sezin, Can, Sumeyra, Hanci, Hayrunisa, Tunc, Fatih, Halici, Hamza, Civelek, Maide Sena, Sevim, Melike, Yurdgulu, Emir Enis, Metin, Onder

Özet

Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H2O2 damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.

Anahtar Kelimeler

Boric acid zinc borate graphene hydrogels viability biocompatibility microbiological analysis BORON GENOTOXICITY GROWTH ROLES

WoS Kategorileri

Engineering, Biomedical Materials Science, Biomaterials

Sürdürülebilir Kalkınma Amaçları

Açlığa Son

Künye

Dergi: JOURNAL OF BIOMATERIALS APPLICATIONS
Yıl: 2025
Cilt: 39
Sayı: 6
Sayfa: 592-606
ISSN: 0885-3282
eISSN: 1530-8022
DOI: 10.1177/08853282241268673
WoS UID: WOS:001316765500001

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