Article 2025 · 6 atıf

Trigonelline alkaloid is effective in preventing doxorubicin-induced lung damage

Uslu, Hamit, Uslu, Gozde Atila, Cicek, Betuel, Bolat, Ismail, Yildirim, Serkan

Özet

BackgroundOne of the most popular chemotherapy medications is doxorubicin (DOX), however it can have non-negligible damage. When the underlying mechanisms of damage are investigated, the most prominent pathways are oxidative stress, inflammation and apoptosis.AimWe investigated the NF-kappa B/MAPK inflammatory pathway and cellular apoptosis to determine the efficacy of trigonelline alkaloid (TRIG) in preventing DOX-induced lung injury.MethodologyThe study consisted of C, TRIG, DOX and TRIG+DOX groups. TRIG and TRIG+DOX groups received 50 mg/kg TRIG for 7 days. On day 8, DOX and TRIG+DOX groups received a single dose of 15 mg/kg DOX.ResultsOur results showed that apoptosis markers and inflammation were higher in the DOX group. In contrast, TRIG pretreatment partially suppressed apoptosis and decreased inflammation by blocking the activation of the MAPK/NF-kappa B pathway, lowering IL-6 levels, and protecting the lung from apoptotic cell death.ConclusionAssessing TRIG's effectiveness in lung tissue injury, this study may be a crucial first step.

Anahtar Kelimeler

Doxorubicin trigonelline alkaloid inflammation apoptosis NF-kappa B/MAPK OXIDATIVE STRESS TOXICITY RAT

WoS Kategorileri

Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Yıl: 2025
Cilt: 131
Sayı: 2
Sayfa: 169-176
ISSN: 1381-3455
eISSN: 1744-4160
DOI: 10.1080/13813455.2024.2404097
WoS UID: WOS:001314376900001

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