Article 2024 · 2 atıf

Biological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase

Usanmaz, Hande, Tas, Omer, Ekinci, Deniz, Uba, Abdullahi Ibrahim, Atmaca, Ufuk

Özet

Aim: A highly efficient one-step method has been developed for the synthesis of benzofuranyl derivatives from 2-benzoylcyclohexane-1-carboxylic acid derivatives using chlorosulfonyl isocyanate. This novel method provides a practical, cost-effective and efficient approach. Materials & methods: The inhibitory effects of benzofuranyl derivatives on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. Ki values were determined to range from 0.009 to 0.61 mu M for AChE and 0.28 to 1.60 mu M for BChE. Molecular docking analysis provided insights into the interaction modes and binding patterns of these compounds with AChE and BChE. Conclusion: Kinetic findings of our study suggest that some of our compounds exhibited more effective low micromolar inhibition compared with the reference, and these derivatives could be to design more powerful agents.

Anahtar Kelimeler

acetylcholinesterase Alzheimer's disease benzofuranyl butyrylcholinesterase molecular modeling CATALYZED CARBONYLATIVE CYCLIZATION ENZYME ACIDS

WoS Kategorileri

Chemistry, Medicinal

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: FUTURE MEDICINAL CHEMISTRY
Yıl: 2024
Cilt: 16
Sayı: 11
Sayfa: 1075-1085
ISSN: 1756-8919
eISSN: 1756-8927
DOI: 10.1080/17568919.2024.2342641
WoS UID: WOS:001236934400001

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