AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation
Cicek, Betul, Hacimuftuoglu, Ahmet, Yeni, Yesim, Kuzucu, Mehmet, Genc, Sidika, Cetin, Ahmet, Yavuz, Emre, Danisman, Betul, Levent, Akin, Ozdokur, Kemal Volkan, Kantarci, Mecit, Docea, Anca Oana, Siokas, Vasileios, Tsarouhas, Konstantinos, Coleman, Michael D., Tsatsakis, Aristidis, Taghizadehghalehjoughi, Ali
The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 mu g/g AuNPs, 1.6 g/kg CS, and 10 mu g/g CS-AuNPs were administered orally simultaneously with 10 mg/ kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-alpha and IL-1 beta levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.
- Dergi
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Yıl
- 2024
- Cilt
- 107
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- DOI
- 10.1016/j.etap.2024.104417
- WoS UID
- WOS:001223389200001