Prognostic potential of copper, zinc, copper/zinc ratio, cobalamin, and serum amyloid A in cats with panleukopenia

Background Copper (Cu), zinc (Zn), and the copper/zinc ratio (Cu/Zn), which have been studied in gastrointestinal disorders of humans, may facilitate disease prognosis. Objective Evaluate the predictive potential of Cu, Zn, cobalamin, and serum amyloid A (SAA) as prognostic indicators in cats with feline panleukopenia (FPV) on admission. Animals Client-owned cats diagnosed with FPV and controls. Methods Serum Cu and Zn concentrations were assessed using the spectrophotometric method and serum concentrations of SAA and cobalamin were measured by chemiluminescent immunoassay. Results On admission, survivor cats with FPV had significantly higher serum Cu and SAA concentrations and Cu/Zn ratios and significantly lower serum Zn and cobalamin concentrations than controls. Furthermore, non-survivor cats with FPV had significantly higher serum Cu and SAA concentrations and Cu/Zn ratios and significantly lower cobalamin concentrations than survivors and controls. Prognostic thresholds were calculated, with positive predictive value (PPV) for survival of 90% for Cu (greater than or similar to 120.3 mu g/dL), 90% for Cu/Zn (greater than or similar to 1.34), 90% for cobalamin (less than or similar to 430.4 pg/mL), and 90% for SAA (greater than or similar to 0.85 mg/L). Conclusions and Clinical Importance Cu (0.93 area under curve [AUC]), Cu/Zn (0.95 AUC), cobalamin (0.98 AUC), and SAA (0.98 AUC) were excellent biomarkers for predicting prognosis in cats with FPV. Their effectiveness, as assessed by sensitivity (100%), specificity (80%), AUC (0.98), and PPV (90%) from receiver operating characteristic analysis, emphasizes the performance of cobalamin and SAA.

Dergi

JOURNAL OF VETERINARY INTERNAL MEDICINE

Yıl

2024

Cilt

38

Sayı

3

Sayfa

1535-1541

ISSN

0891-6640

eISSN

1939-1676

DOI

10.1111/jvim.17077

WoS UID

WOS:001201854400001