Article 2024 · 1 atıf

Protective Effects of Tea Leaf Extract (Camellia sinensis) Against Cypermethrin-Induced Toxicity in Gill and Liver of Rainbow Trout (Oncorhynchus mykiss)

Karatas, Tayfun, Yildirim, Betul Apaydin, Yildirim, Serkan

Özet

Here, we aimed to determine the protective effects of tea leaf extract (TLE) (Camellia sinensis) against cypermethrin (CMN)-induced toxicity in gill and liver of rainbow trout (Oncorhynchus mykiss). CMN exposure led to increase in aspartate aminotransferase (AST), serum alanine aminotransferase (ALT) and malondialdehyde (MDA) levels, and reduction in superoxide dismutase (SOD), catalase (CAT) activities, glutathione (GSH), total immunoglobulin (T. Ig), and white blood cell (WBC) levels. Moreover, CMN exposure led to degeneration, steatosis, and necrosis in liver hepatocytes as well as hyperemia and inflammation in the liver and caused degeneration, desquamation, necrosis and adhesion in the gill epithelium. Additionally, expression levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and Caspase 3 were severe in the liver and gill tissues. However, both 50 and 100 mg doses of TLE had protective effects against CMN-induced toxicity in all the above parameters. As a result, we have shown that 100 mg of tea leaf extract is more effective in preventing harmful effects on blood biochemistry (AST and ALT), oxidative stress, immunity, apoptosis, histopathology and DNA damage caused by CMN.

Anahtar Kelimeler

Fish Tea leaf extract Cypermethrin Oxidative stress Histopathology Immunity FRESH-WATER FISH OXIDATIVE-STRESS ACETYLCHOLINESTERASE ACTIVITY HISTOPATHOLOGICAL PARAMETERS DAMAGE DNA 8-HYDROXY-2-DEOXYGUANOSINE ANTIOXIDANTS ACTIVATION PESTICIDES

WoS Kategorileri

Zoology

Künye

Dergi: PAKISTAN JOURNAL OF ZOOLOGY
Yıl: 2024
Cilt: 56
Sayı: 2
Sayfa: 867-877
ISSN: 0030-9923
DOI: 10.17582/journal.pjz/20221026151015
WoS UID: WOS:001198905100017

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