Article 2023 · 9 atıf

Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage

Guler, Mustafa Can, Akpinar, Erol, Tanyel, Ayhan, comakli, Selim, Bayir, Yasin

Özet

Objective(s): Renal ischemia-reperfusion (I/R) is a vital health condition leading to acute kidney injury. Costunolide (COST) is an actively used molecule clinically for its anti-inflammatory, antioxidant, and immunomodulatory properties. In the present study, we searched for the possible protective effects of COST against renal ischemia/reperfusion (I/R) injury in rats. Materials and Methods: We established a renal I/R rat model. We divided forty rats into four groups: group I (sham), group II (I/R), group III (I/R+COST 5 mg/kg), and group IV (I/R+COST 10 mg/kg). We collected blood, kidney, and lung samples for analysis. Results: COST administration performed anti-oxidant and anti-inflammatory activity by reducing oxidant parameters and proinflammatory cytokine levels. COST alleviated DNA damage through declining 8-hydroxydeoxyguanosine (8-OHdG) levels. In addition, COST diminished tubular damage and inflammation by reducing kidney injury molecule-1 (KIM-1) production. COST administration also ameliorated apoptosis and autophagy by decreasing caspase-3 and microtubule-associated Conclusion: COST demonstrated protective effects against renal I/R-induced injury.

Anahtar Kelimeler

Apoptosis Autophagy Costunolide Rat Renal ischemia-reperfusion KIDNEY INJURY SESQUITERPENE LACTONES OXIDATIVE STRESS MOLECULE-1 KIM-1 CELL BIOLOGY EXPRESSION DEHYDROCOSTUSLACTONE BIOMARKER PROTECTS PATHWAY

WoS Kategorileri

Medicine, Research & Experimental Pharmacology & Pharmacy

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
Yıl: 2023
Cilt: 26
Sayı: 10
Sayfa: 1168-1176
ISSN: 2008-3866
eISSN: 2008-3874
DOI: 10.22038/IJBMS.2023.71779.15596
WoS UID: WOS:001124240800009

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