Article 2024 · 1 atıf

Effect of Ascorbic Acid on Oxidative Stress Parameters of Fruit Fly in the Presence of Fe (II)

Özet

Excessive iron intake causes lipid peroxidation and increases oxidative stress. Ascorbic acid is a natural compound with antioxidant and therapeutic properties. In this study, the effect of AA on oxidative stress parameters in fruit flies in the presence of iron was investigated. Third instar larvae were exposed to Fe and/or AA. Antioxidant enzyme activities, MDA, and GSH levels were determined in adult heads developing from the larvae. The mRNA levels of the enzymes were also analyzed. Iron treatment caused inhibition of SOD, CAT, and GPx enzymes, and only a decrease in the mRNA level of CAT. However, AA treatment together with iron prevented the inhibition. In addition, iron treatment increased the MDA level and decreased the GSH level. AA treatment together with iron ameliorated the changes in MDA and GSH levels. The results showed that AA can interfere with the iron-induced changes. Considering the potential of AA to ameliorate iron-induced changes, further studies are needed to elucidate the effect of AA on different mechanisms.

Anahtar Kelimeler

Antioxidant enzyme Drosophila Iron Vitamin C DROSOPHILA-MELANOGASTER IRON TOXICITY METALS DAMAGE ASSAY MODEL

WoS Kategorileri

Biochemistry & Molecular Biology Endocrinology & Metabolism

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: BIOLOGICAL TRACE ELEMENT RESEARCH
Yıl: 2024
Cilt: 202
Sayı: 8
Sayfa: 3810-3815
ISSN: 0163-4984
eISSN: 1559-0720
DOI: 10.1007/s12011-023-03960-1
WoS UID: WOS:001104715300001

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