Article 2024 · 10 atıf

Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I-II inhibition properties

Ozturk, Cansu, Kalay, Erbay, Gerni, Serpil, Balci, Neslihan, Tokali, Feyzi Sinan, Aslan, Osman Nuri, Polat, Emrah

Özet

The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC50 and Ki values. The Ki values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 +/- 0.022-0.971 +/- 0.280 and 0.025 +/- 0.010-0.682 +/- 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II.

Anahtar Kelimeler

benzothiazole moiety human carbonic anhydrase I human carbonic anhydrase II inhibition secondary sulfonamide derivatives BACTERIAL VITRO

WoS Kategorileri

Biochemistry & Molecular Biology Biotechnology & Applied Microbiology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Yıl: 2024
Cilt: 71
Sayı: 1
Sayfa: 223-231
ISSN: 0885-4513
eISSN: 1470-8744
DOI: 10.1002/bab.2534
WoS UID: WOS:001102034900001

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