Article 2023 · 18 atıf

ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION

Ustundag, Hilal, Kalindemirtas, Ferdane Danisman, Doganay, Songul, Demir, Ozlem, Kurt, Nezahat, Huyut, Mehmet Tahir, Ozgeris, Betul, Kariper, Ishak Afsin

Özet

Sepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, the preventive effects of resveratrol (RV) alone and RV-loaded silver nanoparticles (AgNPs + RV) against sepsis-induced damage were investigated and compared in a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Rats were divided into four groups: Sham, CLP, RV, and AgNPs + RV. Pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) activation, presepsin, procalcitonin (PCT), 8-hydroxy-2 '-deoxyguanosine (8-OHDG), vascular endothelial growth factor (VEGF), and sirtuin-1 (SIRT1) levels were assessed to determine the treatments' effects. AgNPs + RV treatment significantly reduced pro-inflammatory cytokines, NF-kappa B activation, presepsin, PCT, 8-OHDG, and VEGF levels compared with the CLP group, indicating attenuation of sepsis-induced liver injury. Both RV and AgNPs + RV treatments increased SIRT1 levels, suggesting a potential role of SIRT1 activation in mediating the protective effects. In conclusion, AgNPs + RV treatment demonstrated extremely enhanced efficacy in alleviating sepsis-induced liver injury by modulating inflammation, oxidative stress, and endothelial dysfunction, potentially mediated through SIRT1 activation. In this study, the effect of AgNPs + RV on sepsis was evaluated for the first time, and these findings highlight AgNPs + RV as a promising therapeutic strategy for managing sepsis-induced liver injury, warranting further investigation.

Anahtar Kelimeler

Polymicrobial sepsis pro-inflammatory cytokines antioxidant properties liver injury resveratrol silver nanoparticles (AgNPs) IMMUNOSUPPRESSION EXPRESSION MECHANISM RELEASE DAMAGE ASSAY

WoS Kategorileri

Critical Care Medicine Hematology Surgery Peripheral Vascular Disease

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: SHOCK
Yıl: 2023
Cilt: 60
Sayı: 5
Sayfa: 688-697
ISSN: 1073-2322
eISSN: 1540-0514
DOI: 10.1097/SHK.0000000000002218
WoS UID: WOS:001098543500008

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